Title of article
Acute Efavirenz Intoxication in a 16-year-old HIV Negative Girl: A Case Report and Literature Review
Author/Authors
Moghimi ، Minoo Department of Clinical Pharmacy - Faculty of Pharmacy - Mazandaran University of Medical Sciences , Nekoukar ، Zahra Department of Clinical Pharmacy - Faculty of Pharmacy - Mazandaran University of Medical Sciences , Khosravi ، Navid Department of Emergency Medicine - School of Medicine - Mazandaran University of Medical Sciences
From page
73
To page
78
Abstract
Background: There are only rare case reports that revealed the efavirenz (EFV) toxicity. Case Report: This study presents an acute intoxication with 12 g of efavirenz in a 16-year-old healthy girl whose main problem was dose-dependent neurotoxicity. No other serious EFV-related side effects were seen. Previous serious side effects of EFV were observed in HIV-infected patients who underwent long-term combination drug therapy. Conclusion: Accordingly, in terms of the key clinical messages, serious adverse effects of efavirenz are expected to be observed in long-term use in combination with other antiretroviral drugs.
Keywords
Efavirenz , Intoxication , Neurotoxicity , Human immunodeficiency virus , Toxicology
Journal title
Pharmaceutical and Biomedical Research
Journal title
Pharmaceutical and Biomedical Research
Record number
2759223
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