Effect of Sidr honey on production of bacteriocin like inhibitory substances in some pathogenic bacteria

Understanding the link between bacterial growth rate and bacteriocin production is necessary to achieve the highest output. The study aimed to determine the effect of sidr honey on stimulating the formation and release of bacteriocin-like inhibitory substances in pathogenic bacteria. Forty-eight isolates were obtained from different sources, and one isolate of each species (Pseudomonas aeroginoa, Proteus mirabilis, Proteus vulgaris, Staphylococcus aureus, Staphylococcus haemolyticus, Enterobacter cloacae, Salmonella enteric, Escherichia coli. Klebsiella Pneumonaie) were selected to conduct the study. The findings revealed significant differences in the production of BLIS in all isolates, as well as in the growth of bacteria, where there was an increase in both bacterial density and output of BLIS when using a culture medium supplemented with 1% Sidr honey, except for P. mirabilis and Enterobacter cloacae. Intestinal Salmonella and Klebsiella pneumonia, where the density of bacteria decreases when adding 1% of Sidr honey. the addition of sidr honey stimulated the production of BLIS in P. mirabilis. It increased the activity in all isolates, but the density of non-BLIS producers decreased compared to culture media without sidr honey.