Title of article
Alteration in Serum Levels of Tumor Necrosis Factor Alpha is associated with Histopathologic Progression of Gastric Cancer
Author/Authors
Alikhani ، Mehdi HPGC Research Group, Medical Biotechnology Department - Biotechnology Research Center - Pasteur Institute of Iran , Esmaeili ، Maryam HPGC Research Group, Medical Biotechnology Department - Biotechnology Research Center - Pasteur Institute of Iran , Tashakoripour ، Mohammad Gastroenterology Department - Amiralam Hospital - Tehran University of Medical Sciences , Mohagheghi ، Mohammad Ali Cancer Institute - Tehran University of Medical Sciences , Eshagh Hosseini ، Mahmoud Gastroenterology Department - Amiralam Hospital - Tehran University of Medical Sciences , Touati ، Eliette Unit of Helicobacter Pathogenesis - Institut Pasteur , Vosough ، Massoud Department of Regenerative Medicine - Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology - Academic Center for Education, Culture and Research (ACECR) , Mohammadi ، Marjan HPGC Research Group, Medical Biotechnology Department - Biotechnology Research Center - Pasteur Institute of Iran
From page
66
To page
71
Abstract
Background: The role of inflammatory cytokines, such as tumor necrosis- alpha (TNF-α) and IL-8, in gastric carcinogenesis has been investigated, but their impact remains to be further elucidated. Methods: In this study, we measured the serum concentrations of these cytokines and H. pylori serostatus in dyspeptic patients, presenting with normal mucosa (NM = 53), chronic gastritis (CG = 94), and gastric cancer (GC = 82), by ELISA. Results: Moderate levels of TNF-α were detected in the NM group (19.9 ± 19.5 pg/ml), which were nearly doubled in patients with CG (35.7 ± 28.0 pg/ml) and drastically declined in GC patients (1.8 ± 5.9 pg/ml). The serum levels of IL-8, however, were not statistically different amongst these three groups. Conclusion: TNF-α serum concentration seemed to undergo up- and downregulation, when moving from NM to CG and from CG to GC, respectively. If confirmed in a prospective study, this cytokine can behave as a serum indicator of gastric inflammation and malignant transformation.
Keywords
Inflammation , Interleukin , 8 , cytokines , Tumor necrosis factor , alpha
Journal title
Iranian Biomedical Journal(IBJ)
Journal title
Iranian Biomedical Journal(IBJ)
Record number
2761318
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