Title of article
Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in Iranian Patients
Author/Authors
Askari ، Mohammad Cellular and Molecular Research Center - Tehran University of Medical Sciences , Nikpoor ، Amin Reza Department of Immunology - Faculty of Medicine - Mashhad University of Medical Sciences , Aryan ، Hajar Fazeli-Sanati genetic laboratory , Ghaedi ، Hamid Department of Medical Genetics - Shahid Beheshti University of Medical Sciences , Akhtari ، Javad Immunogenetics Research Center, Faculty of Medicine - Mazandaran University of Medical Sciences , Azarnejad ، Asaad Department of Medical Biotechnology - Tehran University of Medical Sciences , Sanati ، Mohammad Hossein National Institute for Genetic Engineering and Biotechnology , Irani ، Alireza Eye Resarch Center, Rassoul Akram Hospital - Tehran University of Medical Sceince , Ghasemi Falavarjani ، Khalil Eye Resarch Center, Rassoul Akram Hospital - Tehran University of Medical Sceince , Nazari ، Hossein Eye Resarch Center, Rassoul Akram Hospital - Tehran University of Medical Sceince , Mousavizadeh ، Kazem Cellular and Molecular Research Center - Tehran University of Medical Sciences
From page
22
To page
27
Abstract
Background: This study aimed at investigating the association between alleles and genotypes of APOE and developing Age-related macular degeneration (AMD). Materials and Methods: After ophthalmological examination, 120 patients with confirmed AMD and 120 healthy controls were enrolled. The polymorphic segment of APOE gene was PCR-amplified and sequenced to determine the frequency distribution of polymorphic alleles and genotypes of this gene in sample population. Results: The frequency distribution of APOE alleles and genotypes differed significantly between the patients and control groups (P 0.05). The frequency of APOEε2 was higher in patients than that of the controls (P = 0.00) and this variant allele showed a significant association with AMD even after removal of the effects of age, sex and smoking in logistic regression analysis (P = 0.00, OR= 3.439; CI 95% 1.664-7.108). On the other hand, the frequency distribution of APOEε4 was not statistically different between patients and healthy controls. Conclusion: The results showed a moderate positive association between APOE ε2 and AMD, but no specific role was found for APOE ε4 in protection against AMD. However, more studies are required to clarify the possible role of APOE in the pathogenesis of AMD.
Keywords
Age , related macular degeneration , Association study , Apolipoprotein E , Vision
Journal title
Research in Molecular Medicine
Journal title
Research in Molecular Medicine
Record number
2761561
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