Title of article
Topical Sevoflurane: A Novel Treatment for Chronic Pain Caused by Venous Stasis Ulcers
Author/Authors
Aranke ، Mayank School of Medicine, Harvard TH Chan School of Public Health - Texas Tech University Health Sciences Center , Pham ، Cynthia T School of Medicine, MedStar Georgetown University Hospital - Georgetown University , Yilmaz ، Melis Harvard Medical School , Wang ، Jason K Harvard Medical School , Orhurhu ، Vwaire Massachusetts General Hospital , An ، Daniel School of Medicine, MedStar Georgetown University Hospital - Georgetown University , Cornett ، Elyse M. Department of Anesthesiology - Louisiana State University (LSU) Health Shreveport , Kaye ، Alan David Department of Anesthesiology - Louisiana State University (LSU) Health Shreveport , Ngo ، Anh L Pain Specialty Group , Imani ، Farnad Department of Anesthesiology and Pain Medicine - Pain Research Center - Iran University of Medical Sciences , Farahmand Rad ، Reza Department of Anesthesiology and Pain Medicine - Pain Research Center - Iran University of Medical Sciences , Varrassi ، Giustino Paolo Procacci Foundation , Viswanath ، Omar Department of Anesthesiology - Louisiana State University (LSU) Health Shreveport , Urits ، Ivan Department of Anesthesiology - Louisiana State University (LSU) Health Shreveport
From page
1
To page
10
Abstract
In the US, an estimated 1 - 2% of chronic venous insufficiency (CVI) patients (of 6 - 7 million nationwide) develop at least one venous stasis ulcer (VSU) during their illness. Of these, approximately 40% develop subsequent ulcers, making VSU prognostically poor. Current management of VSU is costly, with poor prognosis, high recurrence rate, inadequate pain management, and significantly reduced quality of life (QoL). Topical volatile anesthetic agents, such as sevoflurane, offer improved pain relief and symptom control in patients suffering from chronic VSU. The immediate impact of topical sevoflurane in reducing pain associated with ulcer bed debridement has several implications in improving the quality of life in patients with CVI induced ulcers and in the prognosis and healing of the ulcers. This review summarizes a topical formulation of a volatile anesthetic and its implications for the management of VSUs.
Keywords
Sevoflurane , Venous Stasis Ulcer , Pain , Venous Insufficiency , Analgesia , Wound Management
Journal title
Anesthesiology and Pain Medicine
Journal title
Anesthesiology and Pain Medicine
Record number
2762459
Link To Document