Title of article
Effect of Solanum melongena on Components and Kidney Damage of Fructose-Induced Metabolic Syndrome in Rats
Author/Authors
Hernández ، Elizabeth Guzmán Faculty of Higher Studies Iztacala - National Autonomous University of Mexico , González Valle ، Maria del Rosario Histology Laboratory, Morphology and Function Unit - Faculty of Superior Studies Iztacala - National Autonomous University of Mexico , Benítez Flores ، José Carmelo Histology Laboratory, Morphology and Function Unit - Faculty of Superior Studies Iztacala - National Autonomous University of Mexico , Garian Aguilar ، Maria Eugenia Faculty of Higher Studies Iztacala - National Autonomous University of Mexico , San Miguel Chávez ، Rubén Postgraduate College - Montecillo Campus , Hernández Martínez ، Maria Dolores Faculty of Higher Studies Iztacala - National Autonomous University of Mexico , del Valle Mondragón ، Leonardo Department of Pharmacology - Ignacio Chavez National Institute of Cardiology , Segura Cobos ، David Faculty of Higher Studies Iztacala - National Autonomous University of Mexico , Magos Guerrero ، Gil Alfonso Department of Pharmacology - Faculty of Medicine - National Autonomous University of Mexico , López Sánchez ، Pedro Postgraduate Studies and Research Section - Higher School of Medicine - National Polytechnic Institute
From page
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To page
11
Abstract
In traditional Mexican medicine, Solanum melongenais used to treat obesity, diabetes mellitus, hypertension, asthma, bronchitis, arthritis, and hypercholesterolemia. This study examined the effect of treatment with ethanolic extract (EE) from the fruit of S. melongenaon kidney damage on metabolic syndrome (MS). Male Wistar rats were maintained for 12 weeks on a diet of 20% fructose in drinking water and chow to develop MS. After administering EE of S. melongena(100 and 200 mg/kg/day, orally) for 6 weeks, the histological study of the kidney cortex and determination by Western blot of the renal expression of angiotensin II AT1 receptor and cytokine transforming growth factor beta 1 (TGF-β1) were realized. The rats fed with high fructose developed MS and showed kidney damage characterized by proliferative glomerulonephritis and necrosis; this damage was reduced by S. melongenatreatment and associated with decreased expression of AT1 receptor for angiotensin II and cytokine TGF-β1, controlling renal damage in this animal model. In rats affected by MS through high fructose feeding, the treatment with EE of S. melongenashowed a renoprotective effect through decreased expression of AT1 receptor for angiotensin II and cytokine TGF-β1, causes of glomerulonephritis.
Keywords
Solanum melongena , Kidney Damage , AT1 Receptor , Cytokine TGF , β1
Journal title
Iranian Journal of Pharmaceutical Research(IJPR)
Journal title
Iranian Journal of Pharmaceutical Research(IJPR)
Record number
2763346
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