Title of article
A spotlight on gamma-mangostin: exploring its potential as antiviral agents
Author/Authors
Ansori ، Arif Nur Muhammad Postgraduate School - Universitas Airlangga , Murtadlo ، Ahmad Affan Ali Generasi Biologi Indonesia Foundation , Kharisma ، Viol Dhea Generasi Biologi Indonesia Foundation , Muchtaromah ، Bayyinatul Master Program of Biology - Universitas Islam Negeri Maulana Malik Ibrahim , Tamam ، Muhammad Badrut Generasi Biologi Indonesia Foundation , Turista ، Dora Dayu Rahma Generasi Biologi Indonesia Foundation , Rosadi ، Imam Department of Biology - Faculty of Mathematics and Natural Sciences - Mulawarman University , Jakhmola ، Vikash Uttaranchal Institute of Pharmaceutical Sciences - Uttaranchal University , Parashar ، Tarun Uttaranchal Institute of Pharmaceutical Sciences - Uttaranchal University , Saklani ، Taru Uttaranchal Institute of Pharmaceutical Sciences - Uttaranchal University , Rebezov ، Maksim Department of Scientific Research - V. M. Gorbatov Federal Research Center for Food Systems , Zainul ، Rahadian Center for Advanced Material Processing - Universitas Negeri Padang , Purnobasuki ، Hery Department of Biology - Faculty of Science and Technology - Universitas Airlangga , Fadholly ، Amaq School of Veterinary Medicine and Biomedical Sciences - IPB University , Kusala ، Muhammad Research Center for Veterinary Sciences - National Research and Innovation Agency
From page
62
To page
71
Abstract
The global health landscape has seen an upsurge in viral diseases, underlining the urgency for novel antiviral therapies. This mini-review illuminates the potential antiviral capabilities of gamma-mangostin, a xanthone derivative derived from the pericarp of the Garcinia mangostana fruit. Gamma-mangostin’s mechanisms of action are multifaceted, displaying inhibitory effects on viral entry into host cells, disrupting essential cell signalling pathways for viral replication, and enhancing the host’s immune response via antiviral cytokine stimulation. This compound has demonstrated significant in vitro efficacy against numerous viruses, including Influenza A virus, Herpes simplex virus, and Hepatitis C virus, and emerging preliminary research suggests potential utility against SARS-CoV-2. Its broad-spectrum antiviral properties and low cytotoxicity earmark gamma-mangostin as a promising candidate for future antiviral agent development. However, rigorous investigation is required to determine its pharmacokinetics, bioavailability, and safety profile. With the escalating burden of viral diseases, gamma-mangostin could represent an important tool in the armamentarium for disease management, contingent upon further study. This review provides an overview of current research into gamma-mangostin’s antiviral potential and the challenges to its therapeutic development.
Keywords
Gamma , mangostin , Garcinia mangostana , Antiviral , Virus
Journal title
Eurasian Chemical Communications
Journal title
Eurasian Chemical Communications
Record number
2763770
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