Title of article
Impact of electric field exposure on p53 and tnf-α in glioblastoma: An in vivo rat model study
Author/Authors
Herjuna ، Hana Ranu Neurosurgery Department - Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Academic Hospital , Immadoel Haq ، Irwan Barlian Neurosurgery Department - Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Academic Hospital , Wahyuhadi ، Joni Neurosurgery Department - Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Academic Hospital , Parenrengi ، Muhammad Arifin Neurosurgery Department - Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Academic Hospital , Suryaningtyas ، Wihasto Neurosurgery Department - Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Academic Hospital , Purwati ، Purwati Stem Cell Research and Development Center, Institute of Tropical Disease - Universitas Airlangga , Utomo ، Budi Department of Public Health - Faculty of Medicine - Universitas Airlangga , Taruno ، Warsito Purwo C-Tech Labs Edwar Technology - C-Tech Labs Edwar Technology
From page
215
To page
222
Abstract
Glioblastoma is a primary malignant brain tumor with a high recurrence rate and poor prognosis. TNF-α and p53 play significant roles in glioblastoma formation. This experimental in vivo study used a post-test-only control group design to investigate the effects of Electro Capacitive Cancer Treatment (ECCT) on TNF-α and p53 expression in glioblastoma. Glioblastoma cell lines were exposed to ECCT at intensities of 30-50 Vpp and a frequency of 100 kHz for 24 and 72 hours. Results showed that varying ECCT intensity did not affect TNF-α and p53 expression. However, low-intensity electrostatic exposure reduced TNF-α levels compared to the control group, while p53 expression remained unchanged.
Keywords
Glioblastoma , p53 , in vivo , Electric fields. TNF-α ,
Journal title
Eurasian Chemical Communications
Journal title
Eurasian Chemical Communications
Record number
2763817
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