Title of article
Variation of carcinoembryonic antigen (CEA) level in colorectal carcinoma patients in pre-post resection and chemotherapy
Author/Authors
Zuhan ، Arif Doctoral Program of Medical Science - Faculty of Medicine - Hasanudin University , Warsinggih ، Warsinggih Department of Digestive Surgery - Faculty of Medicine - Hasanudin University , Hatta ، Mochammad Mollecular Biology and Immunology Laboratory - Faculty of Medicine - Hasanudin University , Natzir ، Rosdiana Department of Biochemistry - Faculty of Medicine - Hasanudin University , Putranto ، Agi Satria European Virus Bioinformatics Center , Bukhari ، Agussalim Department of Digestive Surgery - Faculty of Medicine, Cipto Mangunkusumo General Hospital - University of Indonesia , Minhajat ، Rahmawati Division of Hematology and Medical Oncology, Internal Medicine Department - Faculty of Medicine - Hasanudin University , Bahar ، Burhanuddin Department of Public Health Medicine - Faculty of Medicine - Hasanudin University , Ermawan ، Sanies Department of Public Health Medicine - Faculty ofMedicine - Hasanudin University , Prabananda ، I. Gede Department of Pathological Anatomy - Mataram City General Hospital , Jumsa ، M. Rizkinov West Nusa Tenggara Province General Hospital - Medical Faculty of Mataram University , Djannah ، Fathul Department of Obstetry and Ginecology - West Nusa Tenggara Province General Hospital - Medical faculty of Mataram University
From page
1079
To page
1085
Abstract
Colorectal carcinoma is the most common disease reported at the West Nusa Tenggara Indonesia. CEA is a glycoprotein that is produced in pathological conditions. This study aims to assess the differences in CEA level at each stage of therapy in patients undergoing adjuvant and neo-adjuvant chemotherapy. This study is an analytic observational study with a crosssectional research design. The study sample included 28 patients and with Wilcoxon and Mann-Whitney tests. There was a statistical significant difference between mean pre-resection CEA and post-resection CEA (p=0.001). There was a significant difference between the mean CEA pre-adjuvant chemotherapy and CEA post-adjuvant chemotherapy (p=0.020). There was also a difference in the mean CEA before neo-adjuvant chemotherapy and CEA after neo-adjuvant chemotheray. There was a significant difference in the CEA post adjuvant chemotherapy and the CEA of post neo-adjuvant chemotherapy (p=0.029). Based on this study, it was found that the pattern of decreasing the average CEA level in each method of therapy. There were significant differences in pre- and post-resection CEA, pre- and post-adjuvant chemotherapy, post-adjuvant chemotherapy and post-neo-adjuvant chemotherapy, which were significant in colorectal carcinoma patients undergoing chemotherapy with the mFOLFOX-7 regimen at the West Nusa Tenggara Regional Hospital.
Keywords
Colorectal carcinoma , CEA , Resection , Adjuvant chemotherapy , Neo , adjuvant chemotherapy
Journal title
Eurasian Chemical Communications
Journal title
Eurasian Chemical Communications
Record number
2763831
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