Title of article
Microneedling with platelet-rich plasma versus using platelet-rich plasma alone for the treatment of atrophic acne scars: A comparative study on clinico-histological features
Author/Authors
Abuamara ، Tamer M.M Center of Oral Diseases Studies, Faculty of Dentistry - Al-Ahliyya Amman University (AAU) , El-Haroun ، Hala Al-Ryada University for Science Technology , Nasr ، Mohamed Histology Department - Faculty of Medicine - Al-Azhar University , Elsharaway ، Ayman F. Histology Department - Faculty of Medicine - Al-Azhar University , Fayed ، Ebrahim M. Histology Department - Faculty of Medicine - Al-Azhar University , Hablas ، Mohamed G.A. Histology and Cell Biology Department - Faculty of Medicine - Suez University , Elzahaby ، Osama M. Histology Department - Faculty of Medicine - Al-Azhar University , El-Nawasany ، Moustafa A.H. Histology Department - Faculty of Medicine - Al-Azhar University , ElSayedf ، Almoatazbellah M. Department of Basic Medical and Dental Sciences - Faculty of Dentistry - Zarqaa University , Mohamed ، Sameh Fawzy F. Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Shawky ، Ahmed Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Ammar ، Amr M. Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Amer ، Mohamed A. Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Mamdouh ، Hassan Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Elrewiny ، Emad Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Risha ، Basma E.M. Dermatology and Venerology Department - Faculty of Medicine for Girls - Al-Azhar University , Elsadiq ، Hala M. Dermatology and Venerology Department - Faculty of Medicine for Girls - Al-Azhar University , Salama ، Omar Abd-ElAziz Mohammad Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Ibrahim ، Ahmed Nabil Maawad Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Sonbol ، Mohamed Mostafa Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Kaabo ، Hassan Fathy Histology Department - Faculty of Medicine - Al-Azhar University , Aladl ، Ahmad S. Venerology and Andrology Department - Faculty of Medicine - Al-Azhar University , Hassan ، Dina A.A Histology Department - Faculty of Medicine for Girls - Al-Azhar University , Ibrahim ، Hany Sabry Ahmed Venerology and Andrology Department - International Islamic Center of Population Studies and Research - Al-Azhar University , Elmaleek ، Doaa Abd Dermatology and Venerology Department - Faculty of Medicine for Girls - Al-Azhar University
From page
1278
To page
1292
Abstract
Platelet-rich plasma (PRP) is an autologous concentrated platelet preparation that could be helpful in the medical care of atrophic acne scars by stimulating collagen synthesis. Skin micro-needling is a method in which a sterile puncture of the skin leads to the release of growth factors. The combination of skin micro-needling with PRP may improve the efficacy of both procedures. The objective of this study was to compare the effectiveness and safety of PRP as a monotherapy for atrophic acne scars with those of micro-needling with PRP. Forty-eight patients with atrophic acne scars were randomly assigned to two equal groups: Group A received an intradermal injection of PRP, and Group B was treated with combined skin needling and PRP. Each participant underwent three months of therapy (four sessions at 1-month intervals). The participants were evaluated before and 3 months after therapy using photography, the Goodman and Baron qualitative grading approach, participants’ satisfaction, and local biopsies. Group B demonstrated a significant improvement over Group A by employing all of the approaches outlined above. The results showed that the combination of micro-needling and PRP produces higher results across all assessment methodologies. There were no statistically significant differences in side effects between our treatment regimens. Although a single therapeutic procedure involving locally injected PRP gives good results in the management of atrophic post-acne scars, combining micro-needling with PRP is more effective. However, both treatments are well-tolerated in all types of atrophic acne scars.
Keywords
acne scars , micro , needling , Platelet , Rich Plasma , special stain , histology
Journal title
Eurasian Chemical Communications
Journal title
Eurasian Chemical Communications
Record number
2763847
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