Synthesis and Biological Evaluation of Five- and Six-Membered Heterocycles as an Anti-Diabetic Agent: An Overview

In medicinal chemistry, heterocycles represent a unique place as a valuable source of therapeutic drugs. Over 75% of pharmaceuticals that are presently on the market and have received FDA approval contain heterocyclic moieties of nitrogen and sulfur. A substantially higher proportion of novel medications based on nitrogen and sulfur is expected in the upcoming ten years. Novel N-heterocyclic moieties have important physiological characteristics and a growing variety of intriguing uses in medicinal chemistry. We have combined the in this review the recent advances on novel 5, 6 membered heterocycles containing nitrogen, sulphur atom, and their unique biological activities that have been documented in the last ten years. The trends in this review are highlighted about 5, 6 membered heterocycles like sulphonamide, pyrimidine based moieties in drug design.