Investigate Complications of COVID-19 Vaccination Among Health Care Workers in Chaharmahal and Bakhtiari, Iran: A Cross-Sectional Study

Background: The COVID-19 pandemic has posed significant challenges to health systems and the global economy. As a result, effective vaccines against Coronavirus disease 2019 (COVID-19) are necessary to reduce the enormous burden of SARS-CoV-2 deaths. However, vaccination may cause side effects (SE) that threaten individuals’ lives. Objectives: This study aimed to evaluate the vaccination status and factors associated with COVID-19 vaccine complications among healthcare workers (HCWs) in Chaharmahal and Bakhtiari province, Iran. Methods: This cross-sectional study was conducted in 2022 on 739 HCWs in Chaharmahal and Bakhtiari province. Healthcare workers were selected by cluster sampling, and their information was collected using a demographic questionnaire and disease history. The data were analyzed using binary logistic regression analysis. Results: Most HCWs (712, 96.3%) were vaccinated. About half of them reported complications after vaccination. More complications were reported in those vaccinated with the Oxford/AstraZeneca vaccine. Male gender, contact with suspected or confirmed COVID-19 patients, COVID-19 history, and type of vaccine were risk factors significantly associated with COVID-19 vaccine complications (P 0.05). Conclusions: This study aimed to investigate vaccination status and factors associated with COVID-19 vaccine complications among HCWs. The Oxford/AstraZeneca vaccine had the most SE, while the BIVI-Cove-Iran vaccine had the fewest SE after the first dose. Additionally, men experienced fewer vaccine SE than women. Healthcare workers have a higher likelihood of facing complications from the COVID-19 vaccine if they have been exposed to infected individuals and have previously contracted the virus.