Budesonide Solubility in 2-Propanol+ Water Mixtures at T = (293.2 to 313.2) K: Experimental Measurement, Thermodynamic Analysis and Mathematical Modeling

A shake-flask method was used to investigate the solubility and thermodynamic properties of budesonide (BDS) in the temperature scope of 293.2-313.22 K in aqueous mixtures of 2-propanol. There are two categories of mathematical models used to fit the experimental data: linear and non-linear cosolvency mathematical models, such as the van’t Hoff’s model, Yalkowsky’s equation, CNIBS/R–K model, Buchowski, and Ksiazczak equation, modified Wilson model, the Williams-Amidon excess Gibbs energy model, and two Jouyban-Acree models: the Jouyban-Acree and the Jouyban-Acree-van’t Hoff. The experimental data for BDS solubility at 298.1 K was also represented with KAT-LSER model. Using back-calculated solubility data, mean relative deviations (MRDs %) of used models were calculated to illustrate fitness and accuracy. Furthermore, van’t Hoff and Gibbs equations have been applied to describe how BDS dissolves in binary solvent mixtures with entropy, enthalpy, and Gibbs free energy included.