Title of article :
Hepatitis B Virus (HBV) and Occult Hepatitis B Virus (OBI) in Hemodialysis Patients: An Epidemiological Observational Study in Kerman, Iran (2022-2023)
Author/Authors :
Nakhaie ، Mohsen Clinical Research Development Unit - Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Afzalipour Hospital - Kerman University of Medical Sciences , Ahmadinejad Farsangi ، Sara Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences Kerman , Rezaei Zadeh Rukerd ، Mohammad Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences , Shafieipour ، Sara Physiology Research Center, Institute of Neuropharmacology - Kerman University of Medical Sciences , Arefinia ، Nasir Student Research Committee - Jiroft University of Medical Sciences , Zahedi ، Mohammad Javad Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences , Mahmoudvand ، Shahab Department of Medical Virology - Faculty of Medicine - Hamadan University of Medical Sciences , Taheri ، Ehsan Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences Kerman , Charostad ، Javad Department of Microbiology - Faculty of Medicine - Shahid Sadoughi University of Medical Sciences
Abstract :
Background and Aim: Viral infections are associated with augmented morbidity and mortality risk in Hemodialysis (HD) patients. Materials and Methods: In this investigation, we have scrutinized the presence of hepatitis B virus (HBV), and occult hepatitis B virus infection (OBI), in HD patients. In this cross-sectional study, the blood samples and data from 200 hemodialysis patients referred to a dialysis center in Kerman, from January 2022 to March 2023 were collected. Anti-HBV antibodies and HBs Ag were analyzed in the specimens using an enzyme-linked immunosorbent assay (ELISA). All samples were tested for OBI by using a real-time polymerase chain reaction (PCR) assay. Results: Of the 200 patients considered, 4 (2%) for HBs Ag were positive. Real-time PCR demonstrated OBI in 2 (1%) patients. The majority presence of viral infection was in the age group 50≥ years, self-employment, low education level, and diabetic patients. Furthermore, our study revealed that a higher percentage of HD patients were associated with low educational levels, self-employment, urban residence, and comorbidities such as diabetes and hypertension. Conclusion: In this study, HBV antigen prevalence was 2%, and OBI prevalence was 1%, indicating a low HBV incidence in HD patients. Our study underscores the importance of lifestyle improvement, increased awareness among lower-educated and lower-skilled individuals, and rigorous disinfection practices in managing risk factors for hemodialysis patients, including HBV and OBI.
Keywords :
Hemodialysis , Hepatitis B virus , Risk Factors , Iran ,
Journal title :
Iranian Journal of Medical Microbiology
Journal title :
Iranian Journal of Medical Microbiology
