Human Papilloma Virus Infection in Iranian Women with Breast Cancer: A Systematic Review

Background: Breast cancer (BC) is one of the most common cancers and health problems in women under the age of 40. Objectives: This systematic study investigates the presence of human papilloma virus (HPV) in Iranian women with BC by searching various international and Iranian databases using standardized keywords. Methods: The inclusion and exclusion criteria were applied to select 22 articles with a total of 2445 BC samples for data extraction and analysis using Statistical Package for the Social Sciences (SPSS) software. Results: The results show that 21.10% of BC samples were HPV positive with Khuzestan, Shahrekord, Mashhad, and Karaj having the highest number of HPV-positive cases among women with BC. Polymerase chain reaction (PCR) was the most used method for detecting HPV in the studies. The distribution of BC samples was highest in Karaj, Tehran, and Golestan. Conclusions: This study provides valuable information about the prevalence of HPV in Iranian women with BC and the geographical distribution of positive cases.