Title of article
The therapeutic effects of erythropoietin and carbamylated erythropoietin derivatives in neurological and other disorders
Author/Authors
Maghsoudi ، Amirhossein Department of Biology - Islamic Azad University, Science and Research Branch , Zaringhalam ، Jalal Physiology Department - School of Medicine - Shahid Beheshti University of Medical Science , Moosavi ، Maryam Nanomedicine and Nanobiology Research Centre, Shiraz Neuroscience Research Center - Shiraz University of Medical sciences , Eidi ، Akram Department of Biology - Islamic Azad University, Science and Research Branch
From page
345
To page
356
Abstract
Erythropoietin (EPO) has been considered in several studies as a significant factor in the development of erythroid cells, the inhibition of neuronal cell death, and neurogenesis. Fortunately, a modified version of EPO called carbamylated erythropoietin (CEPO) possesses tissue-protective properties without eliciting erythropoietic effects. CEPO is a derivative of EPO that results in an alpha-amino derivative group with less biological hematopoiesis than EPO. In neurological diseases, CEPO and its carbamylated erythropoietin Fc fusion protein (CEPO-Fc) has been shown to play a better role than EPO. In this study, the effects of EPO and its derivatives on neurological diseases and their role in treatment have been reviewed.
Keywords
EPO , CEPO , Neurological disorders , Alzheimer’s disease
Journal title
Physiology and Pharmacology
Journal title
Physiology and Pharmacology
Record number
2771561
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