Preparation of Polyhydroquinolines Using Nano Cerium (IV) Oxide/Zinc Oxide as a Catalyst

Polyhydroquinolines derivatives are important compounds that perform a range of biological functions such as vasodilation, anti-atherosclerosis, liver protection, and anti-diabetic. Several drugs such as nifedipine, nicardipine, and Lacidipine feature a polyhydroxyquinoline scaffold. The common synthesis method of polyhydroquinolines is a one-step condensation reaction of Dimedone, aldehydes with ethyl acetate and ammonia in the presence of various catalysts such as MCM-41, molecular iodine, bread yeast, etc. Herein, we report cerium oxide/zinc oxide nanoparticle as an effective and economical catalyst for the four-component, one-pot reaction to synthesize polyhydroquinolines.