Title of article
Human Anti-Toxoplasma Antibodies Attach Strongly to Breast Cancer Cells
Author/Authors
Hosseini ، Fatemeh Department of Medical Parasitology and Mycology - Isfahan University of Medical Sciences , Farahbakhsh ، Zohreh Department of Medical Parasitology and Mycology - Isfahan University of Medical Sciences , Balouti ، Azar Department of Medical Parasitology and Mycology - Isfahan University of Medical Sciences , Kalantari ، Reza Department of Medical Parasitology and Mycology - Isfahan University of Medical Sciences , Pourshahbazi ، Gholamreza Department of Medical Parasitology and Mycology - Isfahan University of Medical Sciences , Mousavi Mobarakeh ، Somayeh Department of Medical Parasitology and Mycology - Isfahan University of Medical Sciences , Yousefi ، Morteza Cancer Research Center - Shahid Beheshti University of Medical Sciences , Yousofi Darani ، Hossein Department of Medical Parasitology and Mycology - Isfahan University of Medical Sciences
From page
1
To page
6
Abstract
Background: Toxoplasma gondiiis the most common intracellular parasite in the human population. The anti-cancer effect of these parasites has been shown, which may be due to the presence of common antigens between the parasite and cancer cells. Objectives: In this work, the reaction of Toxoplasma-positive human sera and Toxoplasma-negative human sera with cell surfaces of 4T1 and MCF7 cell lines have been investigated. Methods: 4T1 and MCF7 cells were harvested from cell cultures and treated with either human Toxoplasma Positive or negative sera. The reaction of the sera was then detected using the flow cytometry method. Results: Toxoplasma-positive sera reacted more strongly with both breast cancer cell lines than Toxoplasma-negative sera. Conclusions: Anti- T. gondiiantibodies strongly react with breast cancer cells. These antibodies may be used for selective cancer immunotherapy in the future.
Keywords
Mcf7 Cells , 4T1 Cells , Toxoplasma , Antisera
Journal title
International Journal of Cancer Management
Journal title
International Journal of Cancer Management
Record number
2772915
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