Is There a Relation between Brain MRI Active Plaques and Cognitive Disorders in Multiple Sclerosis?

Mood disorders could be frequently observed in multiple sclerosis (MS) patients. Mood disorders are common condition in multiple sclerosis with high prevalence rates, for example annually prevalence rate of depression is as high as 20% and lifetime prevalence rates is 50%. In addition it observed that bipolar disoder and other cognitive disorders were common in these patients. However, the comorbidity of  psychiatric problems and amont of  brain damage is not clear. Therfore, this study aimed to investigate the correlation between the active plaques of MS cases’ brain MRI and co-occurrence of different cognitive disorders in the same patients. This literature review project was designed based on standard guidelines to evaluate the related data about brain MRI active plaques and cognitive disorders in multiple sclerosis. The study words, which were combined with each other, were “Mood Disorders”, “Active Plaques”, “Multiple Sclerosis”, “MRI”, “Depression”, “Cognitive disorders”, and “Bipolar Disorder”, the data were extracted and compared. The evaluated studies have represented that there is a correlation between depression and the amount of active plaques on the anterior parietal and left temporal area of the MS patients.