Title of article
Investigating cytotoxicity and the effect of Zn doped CeO2 nanoparticles on tooth-damaging Streptococcus mutans bacteria
Author/Authors
Alirezaei ، Somayeh Oral medicine dept. - faculty of dentistry - Islamic Azad university, Tehran medical sciences branch , Mahmoudi ، Hamed School of dentistry - Tehran university of medical science , Ghodratizadeh ، Soroush Department of Biochemistry - Faculty of Medicine - Urmia University of Medical Sciences , Mohammadi Khah ، Meysam Department of Oral and Maxillofacial Surgery - School of Dentistry, Students’ Research Committee - Shahid Beheshti University of Medical Sciences , Titidej ، Azadehzeinab Oral Maxillofacial Pathology Department - Qazvin University of Medical Sciences
From page
16
To page
23
Abstract
The present study presents a simple method for the provision of pure and 5% zinc doped cerium oxide nanoparticles (Zn-CeO2-NP) through application of extraction from prosopis fracta. In the following, we determined the physical-chemical properties of the product by performance of FESEM, UV-Vis, PXRD, and EDX devices. The finding of PXRD and EDX thoroughly confirmed the existence of zinc inside the structure of CeO2-NP, while results of FESEM measured the particle sizes of pure and doped NP to be below 20 and 10 nm. An assessment was conducted on the cytotoxic performance of synthesized samples on colon cancer (HT-29) cell line through usage of MTT test. According to results, doping process caused an increase in the cytotoxic effect of CeO2-NP. The next section involved the evaluation of obtained antibacterial activity on Streptococcus mutans bacteria via micro-dilution, hence resulted in displaying higher antibacterial activity of doped NP than to pure CeO2-NP.
Keywords
Zn , CeO2 , NP , Prosopis fracta , Streptococcus mutans , MTT assay
Journal title
Nanomedicine Research Journal
Journal title
Nanomedicine Research Journal
Record number
2775002
Link To Document