The role of aerobic training with the Vaccinium Arctostaphylos L. fruit hydro-alcoholic extract in the regulation of oxidative stress in the heart tissue of diabetic rats

Background: Cardiovascular disease is a significant contributor to mortality in diabetic patients. Despite the potential benefits of concomitant and complementary training in diabetic patients, there is a paucity of evidence in this area.Aim: The objective of this study was to investigate the effect of aerobic training in conjunction with a hydroalcoholic extract of the fruit of Qaraqat on superoxide dismutase, glutathione peroxidase, total antioxidant capacity, and malondialdehyde in the heart tissue of male rats with type 2 diabetes.Materials and Methods: 24 male rats aged 8 weeks were diabetic with a high-fat diet (60%) and streptozotocin injection. They were randomly divided into four groups: (1) aerobic training (AT), (2) supplementation (Sup), (3) Aerobic training+ supplement (AT+Sup), and (4) diabetes control (Con). The training protocol included running on a treadmill at a speed of 5-24 m/min for 10-60 min, according to the principle of overload. Glucose, insulin, insulin resistance, and MDA, TAC, GPX, and SOD of heart tissue were measured. Statistical tests of two-way variance and post hoc Bonferroni were used using SPSS software at a significance level of P 0.005.Results A significant decrease in glucose levels, insulin resistance, and MDA (P 0.005) was observed in the intervention groups following eight weeks of training and supplement intervention, in comparison to the Con group. Also, the amount of insulin in Sup and AT+Sup groups exhibited a notable decline in comparison to Con and AT groups (P 0.005), as well as a substantial increase in the levels of SOD (P=0.001) and GPx (P 0.005), and TAC (P 0.005) was observed.Conclusion: Diabetes is associated with elevated MDA levels, which are reduced by aerobic training and supplementation. Furthermore, the administration of a training intervention and the utilization of a supplement have been demonstrated to elevate the levels of SOD, TAC, and GPx.