Title of article :
Advances in Functional Organic-based Nanosystems for RNA Delivery, Targeting Different Organs
Author/Authors :
Motallebi ، Mahzad Nanomedicine Research Association (NRA) - Universal Scientific Education and Research Network (USERN) , Malyen ، Samira Nasibeh School of Nursing and Midwifery - Mazandaran University of Medical Sciences , Ao ، Geriletu Research and Development Center of endoscopic instruments engineering in Zhejiang province, Quzhou People’s Hospital, Quzhou Affiliated Hospital - Wenzhou Medical University
Abstract :
Nucleic acid therapy utilizing ribonucleic acid (RNA) biomacromolecules has attracted considerable attention for being applied as preventive and therapeutic strategies in several diseases including cancer, inflammatory conditions, and neurodegenerative disorders. However, some properties like safety profile, synthesized under good manufacturing procedures, and the fact that RNA molecules, unlike deoxyribonucleic acid (DNA), does not require crossing the nuclear membrane for expression, made them suitable gene materials for being encapsulated in various nano-delivery carriers and delivered precisely to the site of interest. In this article, we summarize the application of organic nano-delivery systems for delivering the two most applied RNA molecules, messenger RNAs (mRNAs) and small interfering RNAs (siRNAs) in different human diseases.
Keywords :
Nano , delivery Systems , mRNA , Cancer , siRNA , Nucleic acid delivery , Organic nanoparticles
Journal title :
Materials Chemistry Horizons
Journal title :
Materials Chemistry Horizons
