Title of article
Stem Cell Therapy in Stargardt Disease: A Systematic Review
Author/Authors
Moghadam Fard ، Atousa Eye Research Center, Five Senses Health Institute, Rassoul Akram Hospital - Iran University of Medical Sciences , Mirshahi ، Reza Eye Research Center, Five Senses Health Institute, Rassoul Akram Hospital - Iran University of Medical Sciences , Naseripour ، Masood Stem Cell and Regenerative Medicine Research Center - Iran University of Medical Sciences , Ghasemi Falavarjani ، Khalil Stem Cell and Regenerative Medicine Research Center - Iran University of Medical Sciences
From page
318
To page
327
Abstract
This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, including human or mouse embryonic stem cells, mesenchymal stem cells, bone marrow mononuclear fraction, and autologous bone marrow-derived stem cells. In addition, different injection techniques including subretinal, intravitreal, and suprachoroidal space injections have been evaluated. Although stem cell therapy holds promise in improving visual function in patients with Stargardt disease, further investigation is needed to determine the long-term benefits, safety, and efficacy in determining the best delivery method and selecting the most appropriate stem cell type.
Keywords
Juvenile , Onset Macular Degeneration , Juvenile , Onset Macular Dystrophy , Stargardt Disease , Stem Cell , Stem Cell Therapy
Journal title
Journal of Ophthalmic and Vision Research
Journal title
Journal of Ophthalmic and Vision Research
Record number
2777601
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