The liver and renal function test in experimentally immunized rabbits with sonicated antigens of Klebsiella pneumoniae

This study aimed to investigate the effect of immunization with sonicated Klebsiella pneumonia on some blood enzymes in rabbits. Using 20 breed rabbits divided into two equal groups (10 each). 1000 µg/ml S/C of sonicated K. Pneumonia antigen was administered to the first group (immunized). The second group was the control which was given 1ml of phosphate buffer saline (pH = 7.2) S/C. According to the results, in the case of liver enzyme, the immunized group had significant increases (P≤0.01) in all blood enzymes (AST, ALT and ALP) at 2, 10, and 20 days compared to the control group. In addition, the renal test (B. urea and creatinine) in the immunized group showed a significant increase in 2 and 10 days compared with zero time or with control, but the results did not show an increase at 20 days.