Nesfatin-1: Relation to oxidative stress and inflammation markers for newly diagnosed myocardial infarction patients in Mosul/Iraq

The discovery of nesfatin-1 was in 2006 as a polypeptide with 82–amino acids. It was widespread central and peripheral distribution gave rise to multiple metabolic effects. In this study, we investigated the relationship between serum nesfatin-1 level with oxidants (peroxynitrite, malondialdehyde, and peroxidase), antioxidants (vitamin E, arylestrase, and uric acid), and markers of inflammation (C-reactive protein and troponin) for newly diagnosed myocardial infarction patients. This study included 158 participants between the ages of (35-75 years) of both genders and was split into two groups: (79) participants of newly diagnosed myocardial infarction patients and (79) healthy people. The results revealed a significant decrease in the level of nesfatin-1 in the patients with newly diagnosed myocardial infarction compared to the control group. It has been found that a significant lower in nesfatin-1 with an increase in BMI and no significant difference between males and females for groups of patients and control. The concentrations of peroxynitrite, malondialdehyde, uric acid, CRP, and troponin significantly increased while there was a significant lower in the concentration of vitamin E and activity of Arylestrase. Using the Pearson correlation coefficient in linear regression analysis revealed nesfatin-1 a negative significant correlation with inflammation markers (troponin and CRP) and oxidants (malondialdehyde and peroxynitrite). We concluded that reduced levels of nesfatin-1 for newly diagnosed myocardial infarction patients in Mosul, Iraq, were affected by BMI but not gender. Therefore, it can be considered as a new indicator and a promising tool for diagnosing initiating, and developing myocardial infarction.