The Effect of Helicobacter Pylori Infection Eradication on Glomerular Filtration Rate in Patients with Chronic Kidney Disease

Aims: Concomitant Helicobacter pylori (H. pylori) infection in patients with chronic kidney disease (CKD) may increase the risk of CKD progression. Maybe the eradication of Helicobacter pylori improves the Glomerular Filtration Rate (GFR), however, there is a challenge between studies. Therefore, this study aimed to demonstrate whether eradication of this infection improves GFR in CKD patients. Materials Methods: This is an interventional study on 270 CKD patients with GFR between 30 to 60 mL/min who were evaluated for H. pylori infection. A total of 79 patients were eligible for inclusion in the study. The patients underwent an early eradication treatment for H. pylori infection. The trend of changes in GFR was evaluated and compared in CKD patients in whom H. pylori infection was successfully eradicated (group A) to those whose infection had not been eradicated (group B) in a six-month follow-up period. Findings: A total of 49 patients with chronic kidney disease (CKD) and a positive stool antigen test for H. pylori completed the study. In Group A, which received treatment for H. pylori infection, the mean glomerular filtration rate (GFR) showed an upward trend, rising from 48.54 ± 8.66 mL/min at baseline to 49.5±14.4 mL/min at six months. However, this increase was not statistically significant (P=0.18). In contrast, Group B exhibited a downward trend in GFR over the study period, decreasing from 45.77±7.92 mL/min at baseline to 45.48±14.33 mL/min at six months, with this change also not reaching statistical significance (p=0.48). Conclusion: There is no significant difference in GFR between groups, however GFR in CKD patients with H. pylori infection eradication is increased.