5-(1H-Benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-Pyrrolium Hexachloroantimonate (BDMP®): A Highly Efficient Immonium Type Peptide Coupling Reagent

HOBt-based immonium type coupling reagent, 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP) has been designed, synthesized and utilized to synthesize oligopeptides and biologically active peptides both in solution and solid phase with good yield, low racemization and fast reaction rate.