Title of article
Synthesis of cis-2-Fluorocyclopropylamine by Stereoselective Cyclopropanation Under Phase-transfer Conditions
Author/Authors
Matsuo، Jun-ichi نويسنده , , Tani، Yu-ichirou نويسنده , , Hayakawa، Yu-ichirou نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
-463
From page
464
To page
0
Abstract
cis-2-Fluorocyclopropylamine is stereoselectively synthesized by cyclopropanation of 3-aryl-2-vinyl-3-(methoxy)isoindol-1-one by treating dibromofluoromethane with saturated aqueous KOH solution in the presence of 18-crown-6 in dichloromethane, followed by removal of a bromine atom of the formed bromofluorocyclopropane derivative with Raney Ni, and successive three steps-deprotection procedures for generating an amino group on the cyclopropane ring.
Keywords
Application-production research , Genetic-fuzzy system , prediction , grinding , Surface finish , Power requirement
Journal title
CHEMISTRY LETTERS
Serial Year
2004
Journal title
CHEMISTRY LETTERS
Record number
27997
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