Enzymatic Synthesis of 3-O-Methylated Chitin Oligomers from New Derivatives of a Chitobiose Oxazoline

Regiospecifically 3-O- and/or 3ʹ-O-methylated derivatives of a chitobiose oxazoline have been synthesized as new substrate monomers and subjected to a chitinase catalysis, leading to the first synthesis of 3-O-methylated chitin oligomers via enzymatic oligomerization.