Structure, Synthesis, and Biological Activity of 14-Methoxy-1,2-dehydrocacalol Methyl Ether, a New Modified Furanoeremophilane Type Sesquiterpene from Trichilia cuneata

A new modified furanoeremophilane type sesquiterpene, (+)-14-methoxy-1,2-dehydrocacalol methyl ether (2), isolated from Trichilia cuneata exhibited inhibitory activity for mitochondrial lipid peroxidation. The first total synthesis of ((plus-minus))-2 and two related sesquiterpenes, ((plus-minus))-14-hydroxycacalol methyl ether (7) and 14-methoxydehydrocacalohastine (8), has also been achieved.