Hybrid Reagent of Ammonium Hydrogen Fluoride and Scandium Triflate: Highly Efficient Catalyst for Ring-opening Fluorination of 2,3-Epoxyalcohols

Ring-opening fluorination of 2,3-epoxy-alcohol is one of the most important ways of introducing fluorine atom into functionalized organic compounds. Catalytic ring-opening fluorination is shown to give excellent yield (88%) by catalytic amount of scandium triflate (Sc(OTf)3) in DME.