Useful Synthesis of Fragment A–C–D of a Thiostrepton-type Macrocyclic Antibiotic, Thiocilline I

Useful synthesis of the main Fragment A–C–D segment constructing a thiostrepton-type macrocyclic antibiotic, thiocilline I, was first achieved by coupling of the 2,3,6-polythiazolesubstituted pyridine skeleton (Fragment A–C) with Fragment D.