Product-catalyzed Mannich-type Reaction between Trimethylsilyl Enolates and N-Tosylaldimines

Mannich-type reaction between trimethylsilyl enolates and N-tosylaldimines in the presence of a catalytic amount of the alkoxide anion proceeded smoothly to afford the corresponding Mannich-adducts in good to high yields. This result indicated that the initially-formed N-anion of Mannich-adduct behaved as an effective Lewis base in performing the product-catalyzed Mannichtype reaction.