One-pot Synthesis of Furo[3,2-c]oxepin-4-one Derivatives by the CAN-mediated Reaction of tert-Butyl 2-(2-Hydroxytetrahydrofuran-2-yl)acetates with Alkenes

The reaction of tert-butyl 2-(2-hydroxytetrahydrofuran-2-yl)acetates with alkenes in the presence of 2 equivalents of cerium(IV) ammonium nitrate (CAN) is presented. 2,3,7,8-Tetrahydrofuro[3,2-c]oxepin-4(6H)-ones were formed in moderate to fair yields via 3+2-type dihydrofuran formation, followed by lactonization.