Title of article
Pharmacological evaluation of [11c]donepezil as tracer for visualization of acetylcholinesterase by PET
Author/Authors
VOS، A. F. DE نويسنده , , Santens، P. نويسنده , , Slegers، G. نويسنده , , Vermeirsch، H. نويسنده , , Dewolf، I. نويسنده , , Dumont، F. نويسنده , , Dierckx، R. A. نويسنده , , Reuck، J. De نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
-744
From page
745
To page
0
Abstract
Donepezil is a highly potent and selective reversible achetylcholinesterase inhibitor. [11C] Donepezil is prepared by methylation with [11C]CH3I of the corresponding 6ʹ-Odesmethylprecursor. Tissue distribution in mice revealed a high uptake in brain and rapid clearance from the blood. Metabolization studies in mice indicated the formation of one 11Clabeled polar metabolite that didnʹt penetrate the blood-brain barrier. Regional brain distribution in rabbits didnʹt reflect the measured achetylcholinesterase distribution in rabbit brain.
Keywords
18F , Acetylcholinesterase , Alzheimers disease , 4-fluorodonepezil
Journal title
NUCLEAR MEDICING & BIOLOGY
Serial Year
2000
Journal title
NUCLEAR MEDICING & BIOLOGY
Record number
29572
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