Author/Authors :
Scheffel، Ursula A. نويسنده , , Dannals، Robert F. نويسنده , , Ravert، Hayden T. نويسنده , , Finley، Paige A. نويسنده , , Mathews، William B. نويسنده , , Frank، Richard A. نويسنده , , Rinaldi-Carmona، Murielle نويسنده , , Barth، Francis نويسنده ,
Abstract :
ABSTRACT. [18F] SR144385 and [18F] SR147963 were synthesized in a multistep reaction in which fluorine-18 was introduced by nucleophilic halogen displacement on a bromo precursor. The fluorine-18-labeled intermediate was deprotected and coupled with the appropriate alkyl amine to give the final products. Both radioligands had appropriate regional brain distribution for cannabinoid receptors with a target to nontarget ratio of 1.7 for [18F] SR147963 and 2.5 for [18F] SR144385 at 60 and 90 min postinjection, respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A.
