Advances in the chemistry of Friedel-Crafts acylation

The scope and application of Friedel-Crafts reactions have proliferated tremendously. The advances in Friedel-Crafts acylation reactions in areas such as regioselective synthesis, new synthetic methods, cycloacylation, synthesis of secondary products of acylation of arenes, stereoselective and other miscellaneous syntheses arc reviewed. Developments in Friedel-Crafts catalysts including Lewis and Bronsted acids, Bronsted-Lewis super acids and zeolites in relation to their utility in the discovery of regiosclective and high yield synthetic technology are discussed.