Nuclear medicine and breast cancer: a review of current strategies and novel therapies

While breast cancer is still increasing in frequency, new diagnostic procedures are now available to challenge existing procedures and to make diagnosis of breast cancer more accurate and reliable. Mammography remains the standard investigation to reveal disease in an asymptomatic population: it can also be used to diagnose breast cancer in symptomatic patients (e.g. those with palpable breast lumps) and for guiding fine needle aspiration (FNA). Because the majority of breast lumps are benign, the challenge is to distinguish benign from malignant lesions without the use of invasive methods and this has attracted nuclear medicine physicians and medical oncologists to investigate the role of scintigraphic procedures to identify which patients require FNA. This review attempts to shed light on the various scintigraphic methods available which are of potential practical use in the assessment of malignant breast disease as well as looking at the possible role of nuclear medicine in the treatment of advanced disease.