LSD response in Eysenckian trait types identified by polypredictive CFA

The four personality type combinations derived from high and low extraversion (E+/E−) and high and low neuroticism (N+/N−) have been related to response patterns composed of three symptoms (affective disturbances, thinking disturbances, and blackouts) scored as present (+) or absent (−) after a single oral dose of the hallucinogenic drug LSD-25. Hypotheses for expected response patterns for each personality group were derived from a data set obtained by Kohnen and Lienert (1987). Significance of associations was tested by two strategies of polyprediction configural frequency analysis (CFA): multiple uniprediction and biprediction CFA. Both strategies yielded a significant hyperpresentation of all three symptoms present in E+N+ (hysterics), merely thinking disorders in dysthymics (E−N+), merely affective symptoms in E+N− (stable extraverts), and merely blackouts in N−E− (stable introverts). Authors tried to relate these symptoms to Kretschmerʹs temperament types and could afterwards show by a chessboard modification of prediction CFA, that by applying two combined hypotheses for two personality types each, the significance of the predicted associations could be increased.