Title of article :
The Incremental Benefit of Rate-Adaptive Pacing on Exercise Performance During Cardiac Resynchronization Therapy Original Research Article
Author/Authors :
Hung-Fat Tse، نويسنده , , Chung-Wah Siu، نويسنده , , Kathy L.F. Lee، نويسنده , , Katherine Fan، نويسنده , , Hon-Wah Chan، نويسنده , , Man-Oi Tang، نويسنده , , Vella Tsang، نويسنده , , Stephen W.L. Lee، نويسنده , , Chu-Pak Lau، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Objectives
The purpose of this research was to investigate the effect of using rate-adaptive pacing and atrioventricular interval (AVI) adaptation on exercise performance during cardiac resynchronization therapy (CRT).
Background
The potential incremental benefits of using rate-adaptive pacing and AVI adaptation with CRT during exercise have not been studied.
Methods
We studied 20 patients with heart failure, chronotropic incompetence (<85% age-predicted heart rate [AP-HR] and <80% HR reserve), and implanted with CRT. All patients underwent a cardiopulmonary exercise treadmill test using DDD mode with fixed AVI (DDD-OFF), DDD mode with adaptive AVI on (DDD-ON), and DDDR mode with adaptive AVI on (DDDR-ON) to measure metabolic equivalents (METs) and peak oxygen consumption (Vo2max).
Results
During DDD-OFF mode, not all patients reached 85% AP-HR during exercise, and 55% of patients had <70% AP-HR. Compared to patients with >70% AP-HR, patients with <70% AP-HR had significantly lower baseline HR (66 ± 3 beats/min vs. 80 ± 5 beats/min, p = 0.015) and percentage HR reserve (27 ± 5% vs. 48 ± 6%, p = 0.006). In patients with <70% AP-HR, DDDR-ON mode increased peak exercise HR, exercise time, METs, and Vo2max compared with DDD-OFF and DDD-ON modes (p < 0.05), without a significant difference between DDD-OFF and DDD-ON modes. In contrast, there were no significant differences in peak exercise HR, exercise time, METs, and Vo2max among the three pacing modes in patients with >70% AP-HR. The percentage HR changes during exercise positively correlated with exercise time (r = 0.67, p < 0.001), METs (r = 0.56, p < 0.001), and Vo2max (r = 0.55, p < 0.001).
Conclusions
In heart failure patients with severe chronotropic incompetence as defined by failure to achieve >70% AP-HR, appropriate use of rate-adaptive pacing with CRT provides incremental benefit on exercise capacity during exercise.
Keywords :
heart rate , VO2max , CRT , LV , left ventricle/ventricular , HR , Vo2 , cardiac resynchronization therapy , Vco2 , peak oxygen consumption , METS , AP-HR , age-predicted heart rate , AVI , atrioventricular interval , metabolic equivalents , peak Vco2/peak Vo2 , peak respiratory exchange ratio , minute carbon dioxide production , minute oxygen consumption
Journal title :
JACC (Journal of the American College of Cardiology)
Journal title :
JACC (Journal of the American College of Cardiology)