Title of article
Familial spastic paraplegia: evidence for a fourth locus
Author/Authors
R. P. M. Bruyn، نويسنده , , M. M. M. van Veen، نويسنده , , H. Kremer، نويسنده , , P. H. Scheltens، نويسنده , , G. W. Padberg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
87
To page
90
Abstract
Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetically heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) to chromosome 15q. We now report a large Dutch family with AD-FSP without linkage to any of these chromosomes, providing evidence for a fourth locus (FSP4).
Keywords
heterogeneity , genetic linkage , Familial spastic paraplegia
Journal title
Clinical Neurology and Neurosurgery
Serial Year
1997
Journal title
Clinical Neurology and Neurosurgery
Record number
463609
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