Central nervous system involvement in systemic connective tissue diseases

Systemic connective tissue diseases can affect the brain, meninges, spinal cord, cranial and peripheral nerves. Different pathogenic mechanisms, particularly autoantibody or T-cell mediated lesions, appear to be involved. The neurological manifestations of the connective tissue diseases and their diagnostic possibilities including newer imaging techniques are reviewed. Early recognition of neurological abnormalities can help in the differential diagnosis and in defining the underlying disease in order to initiate treatment and prevent progression of lesion or cognitive function loss.