Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt–Jakob disease

In a patient with a rapidly progressive neurological condition with ataxia and cognitive complaints, Creutzfeldt–Jakob disease (CJD) is often high in the differential, particularly when there is an elevated CSF 14-3-3 protein level. We present a case of anti-glutamic acid decarboxylase antibody (anti-GAD65) positive cerebellar ataxia associated with cognitive complaints and elevated CSF 14-3-3 protein.