Title of article :
Pathology of hairy-cell leukaemia
Author/Authors :
Kelly J. Bethel، نويسنده , , Robert W. Sharpe، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
17
From page :
15
To page :
31
Abstract :
Hairy-cell leukaemia (HCL) is a low grade B-cell lymphoproliferative process that presents either with lymphocytosis or neutropenia/monocytopenia. It is a disease predominantly of bone marrow and spleen, although it can also involve other organs and sites. Recent advances including multi-parameter flow cytometry and the development of antibodies with high specificity for HCL have permitted precise distinction of typical HCL from other lymphoproliferative diseases that can morphologically mimic the appearance of HCL. Although there is a commonly held belief that HCL is associated with a significant increase in second neoplasms, several recent studies have not supported this notion. The development of extremely effective therapy for HCL results in a high incidence of complete remission. However, a significant percentage of patients continue to harbour minimal residual disease that can be revealed with immunohistochemical and flow cytometric studies.
Keywords :
lymphoma , immunohistochemistry , neoplasm , Receptors , Immunophenotyping , Lymphoma , Cd , leukaemia , leukaemia , leukaemia , Antigens , Residual , leukaemia , hairy cell , hairy cell—pathology , hairy cell—immunology , B-cell , B-cell , interleukin-2.
Journal title :
Best Practice and Research Clinical Haematology
Serial Year :
2003
Journal title :
Best Practice and Research Clinical Haematology
Record number :
467498
Link To Document :
بازگشت