Author/Authors :
Michel Goldman، نويسنده , , Alain Le Moine، نويسنده , , Michel Braun، نويسنده , , Véronique Flamand، نويسنده , , Daniel Abramowicz، نويسنده ,
Abstract :
Eosinophils release inflammatory mediators and cationic proteins that are instrumental in the pathogenesis of allergic diseases such as bronchial asthma. Here, we review experimental observations indicating that eosinophils are also involved in the rejection of allografts. We propose that their role as effectors of transplant damage becomes crucial when classical pathways of rejection are inhibited and T helper 2 (Th2) cells dominate the alloimmune response.
