Nonpolarized memory T cells

Nonpolarized T cells, defined as memory T cells that are deficient in the production of T helper 1 (Th1) or Th2 cytokines, are now receiving overdue attention. Predominantly of a lymphoid-tissue-homing phenotype, they comprise a memory T-cell pool for efficient secondary immune responses, as well as a CXC-chemokine receptor 5 (CXCR5)+ T-cell subset specialized to provide help for B cells. Thus, the conventionally overlooked, nonpolarized T-cell population is proving to have diverse activities important to immune function