• Title of article

    Is the number of genes we possess limited by the presence of an adaptive immune system

  • Author/Authors

    Andrew J. T. George، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2002
  • Pages
    5
  • From page
    351
  • To page
    355
  • Abstract
    The factors that are important in limiting the number of functional genes contained within the genome of an organism are presently unknown. Here, it is suggested that in organisms that contain an adaptive immune response, the number of genes in the genome might be limited by the need to delete autoreactive T cells, thus preventing autoimmunity. The more genes an organism has, the more autoantigens are generated, necessitating an increase in the proportion of T cells that are deleted.
  • Journal title
    Trends in Immunology
  • Serial Year
    2002
  • Journal title
    Trends in Immunology
  • Record number

    468589