Title of article
Is the number of genes we possess limited by the presence of an adaptive immune system
Author/Authors
Andrew J. T. George، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
351
To page
355
Abstract
The factors that are important in limiting the number of functional genes contained within the genome of an organism are presently unknown. Here, it is suggested that in organisms that contain an adaptive immune response, the number of genes in the genome might be limited by the need to delete autoreactive T cells, thus preventing autoimmunity. The more genes an organism has, the more autoantigens are generated, necessitating an increase in the proportion of T cells that are deleted.
Journal title
Trends in Immunology
Serial Year
2002
Journal title
Trends in Immunology
Record number
468589
Link To Document