The immunoregulatory role of IDO-producing human dendritic cells revisited

Following the finding that indoleamine 2,3-dioxygenase (IDO), an enzyme expressed in the placenta, prevents rejection of allogeneic fetuses in mice, many studies have focused on the role of IDO in the regulation of the immune response. Most arguments for an immunoregulatory role of IDO in vivo are based on observations in mice. Here, we critically examine the arguments for and against a function of IDO-expressing human dendritic cells (DCs) and conclude that proof for an immunoregulatory role in vivo is still lacking.