Modulation of wound healing in Swiss albino mice by different doses of gamma radiation

Changes in wound healing were studied using artificial wounds created either by surgical excision of full thickness skin or partial skin thickness dermabrasion of dorsal skin of Swiss albino mice exposed to 2, 4 and 6 Gy of gamma radiation. There was a significant delay in the wound healing process after exposure to 2 Gy when compared to the controls. With increasing doses of radiation wound healing time was also delayed. However, the differences in wound healing times between all three doses were not significant. The irradiation resulted in a dose-dependent delay in the wound contraction and mean wound healing time. The abrasion group was followed until complete epithelialization in the animals exposed to 2, 4 and 6 Gy of gamma radiation. However, no significant difference was observed in the healing time with respect to non-irradiated controls for all the exposure doses used in the present study.