Author/Authors :
Capucine Daridon، نويسنده , , Thomas Guerrier، نويسنده , , Valérie Devauchelle، نويسنده , , Alain Saraux، نويسنده , , Jacques-Olivier Pers، نويسنده , ,
Pierre Youinou، نويسنده ,
Abstract :
Analysis of salivary glands of patients with primary Sjögrenʹs syndrome has yielded conflicting results with respect to T helper (Th)1/Th2 polarization. This balance might parallel the progress of the local lesions. B-cells are now taking center stage in this disease. They can also be primed to differentiate into two cytokine-production pathways, dubbed B effector (Be) 1 and Be2 cells. This is discussed in the light of our recent finding that Be1 accompany Th1, while Be2 accompany in the tissue lesions
